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Masao Hirose Selected Research

diisopropanolnitrosamine

6/2012Prostaglandin synthases influence thyroid follicular cell proliferation but not carcinogenesis in rats initiated with N-bis(2-hydroxypropyl)nitrosamine.
10/2009Inhibitory effects of aminoguanidine on thyroid follicular carcinoma development in inflamed capsular regions of rats treated with sulfadimethoxine after N-bis(2-hydroxypropyl)nitrosamine-initiation.
3/2007Depression of T cell-mediated immunity reduces sulfadimethoxine-induced capsular inflammation and inhibits associated development of invasive thyroid follicular cell carcinomas in rats.
10/2006Lack of enhancement of susceptibility to mammary and thyroid carcinogenesis in rats exposed to DMBA and DHPN following prepubertal iodine deficiency.
6/2006Indomethacin induces small intestinal damage and inhibits amitrole-associated thyroid carcinogenesis in rats initiated with N-bis(2-hydroxypropyl)nitrosamine.
5/2006Absence of in vivo genotoxic potential and tumor initiation activity of kojic acid in the rat thyroid.
5/2006Lung as a new target in rats of 2-amino-3-methylimidazo[4,5-f]quinoline carcinogenesis: results of a two-stage model initiated with N-bis(2-hydroxypropyl)nitrosamine.
1/2006Comparison of enhancing effects of different goitrogen treatments in combination with beta-estradiol-3-benzoate for establishing a rat two-stage thyroid carcinogenesis model to detect modifying effects of estrogenic compounds.
12/2005Enhancement by acrylamide of N-methyl-N-nitrosourea-induced rat mammary tumor development-possible application for a model to detect co-modifiers of carcinogenesis.
8/2005Pronounced synergistic promotion of N-bis(2-hydroxypropyl)nitrosamine-initiated thyroid tumorigenesis in rats treated with excess soybean and iodine-deficient diets.
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Masao Hirose Research Topics

Disease

75Carcinogenesis
06/2012 - 01/2002
51Neoplasms (Cancer)
06/2012 - 01/2002
30Body Weight (Weight, Body)
06/2012 - 01/2002
19Hyperplasia
01/2011 - 04/2002
15Carcinoma (Carcinomatosis)
05/2011 - 01/2002
13Adenoma (Adenomas)
12/2009 - 08/2002
12Adenocarcinoma
08/2008 - 01/2002
9Hypertrophy
01/2011 - 03/2002
6Inflammation (Inflammations)
10/2009 - 03/2004
5Necrosis
06/2009 - 03/2002
5Aberrant Crypt Foci
08/2008 - 01/2002
4Hypothyroidism
08/2012 - 11/2009
3Colorectal Neoplasms (Colorectal Cancer)
08/2012 - 08/2003
2Lymphoma (Lymphomas)
11/2019 - 03/2003
2Leukemia
11/2019 - 08/2003
2Atrophy
01/2008 - 01/2002
2Breast Neoplasms (Breast Cancer)
08/2003 - 01/2003

Drug/Important Bio-Agent (IBA)

19diisopropanolnitrosamineIBA
06/2012 - 04/2002
16CarcinogensIBA
02/2010 - 06/2002
15Drinking WaterIBA
07/2010 - 04/2002
10SulfadimethoxineIBA
06/2012 - 03/2004
10Sodium NitriteIBA
08/2008 - 04/2002
9SDMIBA
06/2012 - 03/2004
8Proteins (Proteins, Gene)FDA Link
08/2012 - 06/2002
7AntioxidantsIBA
01/2008 - 01/2002
71,2-Dimethylhydrazine (1,2 Dimethylhydrazine)IBA
10/2007 - 02/2002
72- amino- 1- methyl- 6- phenylimidazo(4,5- b)pyridineIBA
04/2006 - 01/2002
6Dimenhydrinate (DMH)FDA LinkGeneric
10/2007 - 02/2002
5Antithyroid Agents (Antithyroid Drugs)IBA
06/2012 - 03/2004
5nitrosobis(2-oxopropyl)amine (NBOP)IBA
03/2011 - 04/2002
59,10-Dimethyl-1,2-benzanthraceneIBA
01/2007 - 07/2002
5benzocycloheptapyridineIBA
04/2006 - 02/2002
4PropylthiouracilFDA Link
08/2012 - 01/2006
4Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA
06/2012 - 04/2003
4Capsules (Microcapsules)IBA
04/2011 - 03/2004
4Phenobarbital (Luminal)FDA Link
11/2008 - 06/2002
4Ascorbic Acid (Vitamin C)FDA LinkGeneric
08/2008 - 12/2002
4Dextrans (Dextran)FDA Link
10/2007 - 08/2003
4sodium sulfate (sodium bisulfate)FDA LinkGeneric
10/2007 - 08/2003
4IodineIBA
10/2006 - 04/2003
4anthraceneIBA
10/2006 - 07/2003
4benzyl isothiocyanateIBA
09/2006 - 01/2002
4AminesIBA
04/2005 - 01/2002
4phenethyl isothiocyanate (PEITC)IBA
03/2005 - 03/2003
4Ethylnitrosourea (N-Ethyl-N-nitrosourea)IBA
09/2003 - 06/2002
3DNA (Deoxyribonucleic Acid)IBA
11/2019 - 04/2009
3Methimazole (Thiamazole)FDA LinkGeneric
08/2012 - 11/2009
3Indomethacin (Indometacin)FDA LinkGeneric
06/2012 - 06/2006
3nimesulide (Aulin)IBA
06/2012 - 04/2003
3SmokeIBA
03/2011 - 01/2002
3Thyroxine (Levothyroxine)FDA LinkGeneric
01/2011 - 06/2003
3Methylnitrosourea (N-Methyl-N-nitrosourea)IBA
02/2010 - 12/2005
3Codon (Codons)IBA
10/2009 - 09/2003
3QuinoxalinesIBA
08/2008 - 01/2002
3Nitric Oxide (Nitrogen Monoxide)FDA Link
08/2008 - 03/2006
3perilla seed oilIBA
04/2008 - 01/2002
3Diethylnitrosamine (N-Nitrosodiethylamine)IBA
07/2007 - 01/2003
3Methylnitronitrosoguanidine (MNNG)IBA
07/2007 - 04/2002
3TeaIBA
07/2007 - 01/2002
3arctiinIBA
01/2007 - 01/2002
3Hormones (Hormone)IBA
08/2005 - 01/2003
3Caffeine (No Doz)FDA LinkGeneric
05/2004 - 01/2002
3estradiol 3-benzoate (estradiol benzoate)IBA
09/2003 - 07/2002
3Phenolphthalein (Modane)IBA
03/2003 - 06/2002
2Phosphatidylinositols (Phosphatidylinositol)IBA
05/2011 - 04/2011
2EnzymesIBA
03/2011 - 02/2008
2Uridine Diphosphate (UDP)IBA
03/2011 - 03/2006
2Triiodothyronine (Liothyronine)FDA LinkGeneric
01/2011 - 12/2009
2Thyrotropin (Thyroid-Stimulating Hormone)FDA Link
12/2009 - 08/2005
2alizarinIBA
12/2009 - 04/2009
2rubiadinIBA
12/2009 - 04/2009
2Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA
10/2009 - 03/2007
2Glutathione Transferase (Glutathione S-Transferase)IBA
06/2009 - 01/2002
2madder colorIBA
04/2009 - 01/2009
2potassium perchlorateFDA Link
03/2009 - 01/2006
2IronIBA
11/2008 - 02/2008
2AcidsIBA
08/2008 - 01/2008
2beta CateninIBA
10/2007 - 03/2004
2Cyclooxygenase 2 (Cyclooxygenase-2)IBA
09/2006 - 01/2005
2Amitrole (Aminotriazole)IBA
06/2006 - 02/2005
2quinolineIBA
05/2006 - 05/2006
2kojic acidIBA
05/2006 - 06/2003
28-Hydroxy-2'-DeoxyguanosineIBA
03/2006 - 01/2003
2Cytochrome P-450 CYP1A2 (CYP1A2)IBA
03/2006 - 01/2002
2Butylated Hydroxytoluene (BHT)IBA
01/2006 - 08/2002
2Estrogens (Estrogen)FDA Link
01/2006 - 06/2005
2Endocrine DisruptorsIBA
01/2006 - 04/2002
2Diethylhexyl Phthalate (DEHP)IBA
01/2005 - 07/2002
2AtrazineIBA
01/2005 - 12/2003
2DNA AdductsIBA
11/2003 - 04/2002
2ButylhydroxybutylnitrosamineIBA
11/2003 - 01/2002
2LignansIBA
10/2003 - 01/2002
2Proliferating Cell Nuclear Antigen (PCNA)IBA
09/2003 - 04/2002
2Safflower OilFDA Link
07/2003 - 04/2002
2Conjugated Linoleic AcidsIBA
07/2003 - 04/2002
2Fatty Acids (Saturated Fatty Acids)IBA
07/2003 - 04/2002

Therapy/Procedure

6Subcutaneous Injections
06/2006 - 04/2002
5Intraperitoneal Injections
07/2007 - 06/2002
4Ovariectomy (Oophorectomy)
01/2007 - 07/2002
3Chemoprevention
02/2003 - 01/2002